Document 0498
 DOCN  M9550498
 TI    An experimental study of primary feline immunodeficiency virus infection
       in cats and a historical comparison to acute simian and human
       immunodeficiency virus diseases.
 DT    9505
 AU    Dua N; Reubel G; Moore PF; Higgins J; Pedersen NC; Department of
       Medicine and Epidemiology, School of Veterinary; Medicine University of
       California, Davis 95616.
 SO    Vet Immunol Immunopathol. 1994 Nov;43(4):337-55. Unique Identifier :
       AIDSLINE MED/95159407
 AB    Sixteen adolescent specific pathogen free cats were inoculated with the
       Petaluma strain of feline immunodeficiency virus (FIV) and two cats were
       then necropsied at each of 5, 10, 21, 28, 42, 56, 70, and 84 day time
       points following infection. Lymphadenopathy gradually increased starting
       at Day 10 and persisted for the duration. Gross clinical signs of fever,
       mild to severe malaise, anorexia, diarrhea, dehydration, and generalized
       soreness appeared around Day 42, peaked at Day 56, and disappeared by
       Days 70-84 post-infection. Leukopenia, associated initially with a mild
       lymphopenia and later by both a mild lymphopenia and a severe
       neutropenia, appeared 14-28 days following infection, troughed at Day
       56, and persisted thereafter. The CD4+:CD8+ T cell ratio started to
       decrease around Day 28, reaching a nadir at Days 56-70. This decrease
       was due to a decline in the absolute numbers and percentage of CD4+ T
       cells and an increase in the percentage of CD8+ T cells. Significant
       histopathologic lesions included myeloid hyperplasia between Days 56-70
       post-infection; thymitis with cortical involution and follicular
       hyperplasia starting at Day 42; lymphoid hyperplasia of peripheral and
       mesenteric nodes, spleen and tonsils beginning around Day 42; typhlitis
       most evident from Day 56 onward, and an interstitial nephritis and
       pneumonitis that was most intense after Day 42. Virus was isolated from
       peripheral blood mononuclear cells (PBMC) beginning 2 weeks
       post-infection, and plasma viremia appeared 1 week later. Plasma and
       PBMC-associated viremia peaked at 42-56 days following infection and
       decreased abruptly thereafter. Proviral DNA was detectable as early as 5
       days after infection in blood leukocytes and after 10 days in other
       organs. The central nervous system, lungs, thymus, tonsils and
       mesenteric lymph nodes were the earliest sites of virus localization.
       Antibodies to the FIV capsid protein appeared 14 days following
       infection and reached peak levels by Days 42-56. Abnormalities occurring
       during the primary stage of FIV infection were consistent with those
       described for acute simian and human immunodeficiency virus-induced
       disease.
 DE    Acquired Immunodeficiency Syndrome/*IMMUNOLOGY/PATHOLOGY  Animal
       Antibodies, Viral/ANALYSIS  Cats  Comparative Study  CD4-Positive
       T-Lymphocytes/IMMUNOLOGY/VIROLOGY  CD8-Positive
       T-Lymphocytes/IMMUNOLOGY/VIROLOGY  DNA, Viral/ANALYSIS  Feline Acquired
       Immunodeficiency Syndrome/*IMMUNOLOGY/PATHOLOGY  Human  Immunodeficiency
       Virus, Feline/ISOLATION & PURIF  Macaca  Proviruses/GENETICS  Simian
       Acquired Immunodeficiency Syndrome/*IMMUNOLOGY/PATHOLOGY  Specific
       Pathogen-Free Organisms  Support, U.S. Gov't, P.H.S.
       Viremia/*IMMUNOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).