Document 0502
 DOCN  M9550502
 TI    Porcine T-cell receptors: molecular and biochemical characterization.
 DT    9505
 AU    Thome M; Hirt W; Pfaff E; Reddehase MJ; Saalmuller A; Federal Research
       Centre for Virus Diseases of Animals, Tubingen,; Germany.
 SO    Vet Immunol Immunopathol. 1994 Oct;43(1-3):13-8. Unique Identifier :
       AIDSLINE MED/95159371
 AB    Two subclasses of CD3 associated T-cell receptors (TcR) have been
       described so far, consisting of either an alpha and beta chain (TcR
       alpha beta) or a gamma and delta chain (TcR gamma delta). Of the two
       subclasses, the TcR alpha beta is the one predominantly expressed on
       peripheral T lymphocytes of humans and rodents. TcR gamma delta T
       lymphocytes represent only a minor subset in these species. Among all
       mammalian species studied so far, swine showed the most diversified
       composition of the T-lymphocyte population characterized by the
       expression of CD4 and CD8 differentiation antigens. Besides CD4+CD8- and
       CD4-CD8+ T lymphocytes, CD4+CD8+ and CD4-CD8- T lymphocytes are
       prominent in the extrathymic T-lymphocyte compartment. Because of the
       lack of specific monoclonal antibodies (mAb), to date the porcine TcR
       can only be characterized with biochemical and molecular biological
       methods. TcR on porcine peripheral blood T lymphocytes with the
       phenotype CD4+ and/or CD8+ are characterized as 46-48 kDaR heterodimers
       which were supposed to represent the porcine TcR alpha beta. Biochemical
       analyses of the CD4-CD8- T lymphocytes revealed three distinct TcR gamma
       delta; all are characterized by a 40 kDa delta chain but differed in
       their gamma chains. One gamma chain with a molecular mass of 38 kDaR is
       preferentially expressed on CD4-CD8- T lymphocytes derived from
       peripheral blood; another chain with molecular mass of 37 kDaR is evenly
       distributed between CD4-CD8- T lymphocytes from blood and lymphoid
       tissues.(ABSTRACT TRUNCATED AT 250 WORDS)
 DE    Amino Acid Sequence  Animal  Antigens, CD3/IMMUNOLOGY  CD4-Positive
       T-Lymphocytes/IMMUNOLOGY  CD8-Positive T-Lymphocytes/IMMUNOLOGY
       Immunophenotyping  Molecular Sequence Data  Receptors, Antigen, T-Cell,
       alpha-beta/*GENETICS/IMMUNOLOGY  Receptors, Antigen, T-Cell,
       gamma-delta/*GENETICS/IMMUNOLOGY  Swine/*IMMUNOLOGY  JOURNAL ARTICLE
       REVIEW  REVIEW, TUTORIAL

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