Document 0508
 DOCN  M9550508
 TI    Chest radiography and beta-2-microglobulin levels in HIV-seronegative
       and HIV-seropositive African patients with pulmonary tuberculosis.
 DT    9505
 AU    Richter C; Pallangyo KJ; Ndosi BN; Chum HJ; Swai AB; Shao J; Department
       of Medicine, Ministry of Health, Dar es Salaam,; Tanzania.
 SO    Trop Geogr Med. 1994;46(5):283-7. Unique Identifier : AIDSLINE
       MED/95159216
 AB    To examine the relationship between radiographic features, serum
       beta-2-microglobulin (beta-2-M) levels, results of sputum-smear
       microscopy and outcome, we performed a retrospective study of 99
       HIV-seropositive and 162 HIV-seronegative patients with pulmonary
       tuberculosis (TB) in Dar es Salaam, Tanzania. Radiographic features of
       primary TB were more common and features of postprimary TB less common
       in HIV-seropositive compared to seronegative patients (50% vs 31%, p <
       0.002; and 40% vs 63%, p < 0.001), respectively). HIV infection had a
       strong independent effect on the beta-2-M levels. Among HIV-infected
       patients radiographic findings of primary TB were significantly more
       often associated with beta-2-M levels of > 4 mg/l than features of
       postprimary TB (71.1% vs 44.4%, p < 0.02). In patients with features of
       postprimary TB, acid-fast bacilli were more often detected in sputum
       smears than in patients with primary TB (65% vs 47%, p > 0.05, in
       HIV-seropositive patients; and 63% vs 31%, p < 0.001) in seronegative
       patients). The observed mortality was too low to identify radiographic
       predictors of survival. We conclude that HIV-infected patients with
       features of primary pulmonary TB are likely in an advanced stage of HIV
       infection and deserve close supervision during anti-tuberculous therapy.
 DE    beta 2-Microglobulin/*METABOLISM  Adult  AIDS-Related Opportunistic
       Infections/BLOOD/EPIDEMIOLOGY/  *RADIOGRAPHY  Female  Human  HIV
       Seropositivity  Male  Middle Age  Prevalence  Retrospective Studies
       Sputum/MICROBIOLOGY  Support, Non-U.S. Gov't  Tanzania/EPIDEMIOLOGY
       Tuberculosis, Pulmonary/BLOOD/COMPLICATIONS/EPIDEMIOLOGY/  *RADIOGRAPHY
       JOURNAL ARTICLE

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