Document 0521
 DOCN  M9550521
 TI    Markers of immune stimulation in the cerebrospinal fluid during HIV
       infection: a longitudinal study.
 DT    9505
 AU    Gisslen M; Chiodi F; Fuchs D; Norkrans G; Svennerholm B; Wachter H;
       Hagberg L; Department of Infectious Diseases, University of Goteborg,;
       Sweden.
 SO    Scand J Infect Dis. 1994;26(5):523-33. Unique Identifier : AIDSLINE
       MED/95158827
 AB    Markers of immune stimulation were studied in 76 sequential
       cerebrospinal fluid (CSF) samples from 19 patients infected with HIV-1
       without antiretroviral treatment during observation periods ranging from
       22 months to 6 years. Eight of these patients were further followed with
       14 CSF samples for 3-24 months of zidovudine treatment. During the
       course of HIV-1 infection, the mean CSF neopterin and beta
       2-microglobulin (beta 2M) concentrations increased from 12.7 to 20.4
       nmol/l (p < 0.01) and from 1.93 to 2.17 mg/l (p < 0.05), respectively,
       while the mean peripheral CD4 + T cell count decreased from 624 to 320
       cells x 10(6)/l (p < 0.001). The IgG index, reflecting intrathecal
       immunoglobulin production, increased from 0.72 to 0.92 (p = 0.08). The
       number of patients with CSF pleocytosis did not change significantly
       during follow-up (8/19 at baseline, 7/19 at endpoint). In the 8 patients
       followed up during antiretroviral treatment, a significant reduction in
       mean CSF levels of neopterin and beta 2M (-48% and -32%, respectively, p
       < 0.01) was seen after 3-12 months on zidovudine. We suggest that
       gradual increase in immune stimulation reflected by the rising CSF
       concentrations of neopterin and beta 2M indicates that HIV-1 infection
       in the central nervous system is progressive even in neurologically
       asymptomatic stages.
 DE    beta 2-Microglobulin/*CEREBROSPINAL FLUID  Adult  Aged  Biological
       Markers/CEREBROSPINAL FLUID  Biopterin/*ANALOGS &
       DERIVATIVES/CEREBROSPINAL FLUID  Comparative Study  Female  Human  HIV
       Infections/*CEREBROSPINAL FLUID/DRUG THERAPY/*IMMUNOLOGY  HIV
       Seropositivity/CEREBROSPINAL FLUID/IMMUNOLOGY  HIV-1/*IMMUNOLOGY
       Longitudinal Studies  Male  Middle Age  Monitoring, Immunologic
       Zidovudine/THERAPEUTIC USE  JOURNAL ARTICLE

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