Document 0533
 DOCN  M9550533
 TI    Thrombotic thrombocytopenic purpura as the cause of death in an
       HIV-positive child.
 DT    9505
 AU    Jorda M; Rodriguez MM; Reik RA; University of Miami/Jackson Memorial
       Hospital, Department of; Pathology, Florida.
 SO    Pediatr Pathol. 1994 Nov-Dec;14(6):919-25. Unique Identifier : AIDSLINE
       MED/95158257
 AB    A case of fatal thrombotic thrombocytopenic purpura (TTP) in a pediatric
       patients with HIV infection is reported. The diagnosis was made at
       autopsy based on the presence of platelet microthrombi in multiple
       organs, including the cardiac conduction system. The disease presented
       atypically with hemorrhagic manifestations, thrombocytopenia, and
       hemolytic anemia, without significant accompanying neurologic and renal
       abnormalities. Autoimmune-based thrombocytopenia has been well
       documented in the presence of HIV infection in both the adult and the
       pediatric population. We believe this to be the first reported case of
       TTP in an HIV-positive child.
 DE    Case Report  Child, Preschool  Fatal Outcome  Human  HIV
       Infections/*COMPLICATIONS  Lymph Nodes/PATHOLOGY  Male
       Myocardium/PATHOLOGY  Purpura, Thrombotic
       Thrombocytopenic/COMPLICATIONS/*PATHOLOGY  Thymus Gland/PATHOLOGY
       JOURNAL ARTICLE

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