Document 0537
 DOCN  M9550537
 TI    Increased soluble CD8 (sCD8) in human immunodeficiency virus 1-infected
       children in the first month and year of life.
 DT    9505
 AU    Gesner M; Di John D; Krasinski K; Borkowsky W; Department of Pediatrics,
       New York University Medical Center, NY; 10016.
 SO    Pediatr Infect Dis J. 1994 Oct;13(10):896-8. Unique Identifier :
       AIDSLINE MED/95158128
 AB    The purpose of this study was to determine whether soluble CD8 (sCD8) in
       serum of perinatally human immunodeficiency virus 1 (HIV-1)-infected
       children during the first year of life differs from that of
       HIV-1-uninfected control children. Soluble CD8 concentrations in stored
       plasma and serum samples of children of HIV-1-infected and uninfected
       mothers were determined using a sandwich immune assay. In the first
       month of life significantly greater concentrations of sCD8 occurred in
       12 HIV-1-infected infants than in 9 uninfected infants born to infected
       mothers (mean = 1054, SD 540 vs. 589, SD 370 units/ml, P < 0.05),
       although the CD8+ T cell proportions were not different (21.7 vs. 21.1,
       P > 0.5). The difference in sCD8 concentrations was most pronounced in 8
       infants who were HIV-1 culture positive on initial testing in the first
       week of life compared with the remaining 4 patients when virus was first
       detected on subsequent analysis (mean = 1315, SD 446 vs. 529, SD 231
       units/ml, P < 0.01). The concentration of sCD8 was also greater in 26
       HIV-1-infected children than in either 26 uninfected children born to
       infected mothers or 25 seronegative children during the first year of
       life (mean = 1268, SD 529 vs. 630, SD 290 vs. 553, SD 315 units/ml, P <
       0.05). Early and persistent elevation in sCD8 probably reflects immune
       activation resulting from HIV-1 infection. The occurrence of this
       increase in the neonatal period may reflect prenatal viral transmission,
       a higher viral inoculum or coinfection with other agents stimulating
       immune activation.
 DE    Analysis of Variance  AIDS Serodiagnosis  Case-Control Studies
       Cross-Sectional Studies  CD8-Positive T-Lymphocytes/*IMMUNOLOGY  Disease
       Transmission, Vertical  Human  HIV
       Infections/*CONGENITAL/*IMMUNOLOGY/TRANSMISSION  HIV-1/*IMMUNOLOGY
       Infant  Infant, Newborn  Retrospective Studies  Support, Non-U.S. Gov't
       Support, U.S. Gov't, P.H.S.  T-Lymphocyte Subsets/*IMMUNOLOGY  JOURNAL
       ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).