Document 0539
 DOCN  M9550539
 TI    [Adherence of isolated Candida albicans strains from HIV+ infected
       patients to buccal epithelial cells: correlation with serotype,
       sensitivity to fluconazole and virulence]
 DT    9505
 AU    Imbert-Bernard C; Valentin A; Reynes J; Mallie M; Bastide JM;
       Laboratoire de Parasitologie-Immunologie, UFR des Sciences;
       Pharmaceutiques, Faculte de Pharmacie, Montpellier, France.
 SO    Pathol Biol (Paris). 1994 Jun;42(6):567-73. Unique Identifier : AIDSLINE
       MED/95158093
 AB    During infection by human immunodeficiency virus (HIV), oral
       pseudomembranous candidiasis frequency is high. Adherence of Candida
       albicans to epithelial cells constitutes one of the first step in the
       setting up of candidiasis. Adherence ability of Candida albicans to
       buccal epithelial cells (BEC) is estimated for 83 isolates. The yeasts
       are isolated from buccal swabs from HIV+ patients with clinical
       oropharyngeal candidiasis. Results show that Candida albicans ability to
       adhere to BEC is variable within isolates; it appears that most of the
       isolates are weakly adherent. In addition, adherence is not correlated
       with the serotype A or B of yeasts. We do not either observe any
       correlation between adherence capacity and sensibility of yeasts to
       fluconazole. Moreover, no correlation is observed between a group of 13
       genetically identical isolates (analysed on 21 loci with isoenzymes
       method) and their adherence to BEC. Finally, Candida albicans virulence,
       which is studied in vivo on intravenously infected mouse model, does not
       seem to be correlated with capacity of each yeast to adhere on BEC in
       vitro.
 DE    AIDS-Related Opportunistic Infections/COMPLICATIONS/MICROBIOLOGY
       Bacterial Adhesion/*PHYSIOLOGY  Candida albicans/CLASSIFICATION/DRUG
       EFFECTS/*PHYSIOLOGY/  PATHOGENICITY
       Candidiasis/COMPLICATIONS/*MICROBIOLOGY  English Abstract
       Fluconazole/PHARMACOLOGY  Human  HIV Infections/*COMPLICATIONS  In Vitro
       Mouth Mucosa/*MICROBIOLOGY  Serotyping  Virulence  JOURNAL ARTICLE

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