Document 0555
 DOCN  M9550555
 TI    [Fluconazole sensitivity of Candida strains in vitro in the
       microdilution test and agar diffusion test]
 DT    9505
 AU    Metzger S; Jager H; Hofmann H; Dermatologische Klinik und Poliklinik der
       Technischen; Universitat, Munchen.
 SO    Mycoses. 1994;37 Suppl 1:64-70. Unique Identifier : AIDSLINE
       MED/95157581
 AB    The comparison of the in vitro-susceptibility of Candida isolates
       collected from the oral cavity of different groups of patients to
       fluconazole ist reported. The isolates of HIV-patients treated with
       fluconazole, HIV-patients and dermatological patients without
       fluconazole exposure were investigated. The in vitro-susceptibility of
       these isolates was determined by microdilution test and agar diffusion
       test. 88.7% of the 194 Candida isolates were susceptible in vitro, 6.7%
       less sensitive and 4.6% resistant to fluconazole. Comparing the
       susceptibility within the groups there was a higher number of isolates
       less sensitive (14.7%) and resistant (11.8%) to fluconazole in the group
       of HIV-patients treated with fluconazole than in the other 2 groups
       without treatment. The less sensitive isolates were 4 C. albicans and 6
       C. glabrata. The resistant isolates were 2 C. albicans, 2 C. glabrata
       and 4 C. krusei. In the group of HIV-patients without fluconazole
       exposure there were only 2.7% of the isolates less sensitive (2 C.
       glabrata) and 1.4% resistant to fluconazole (1 C. glabrata). In
       dermatological patients there were 2% of the isolates less sensitive (2
       C. glabrata) and no resistant isolate. Resistance both in vivo and in
       vitro was found in 2 patients.
 DE    AIDS-Related Opportunistic Infections/DRUG THERAPY/*MICROBIOLOGY
       Candida/*DRUG EFFECTS  Candidiasis, Oral/DRUG THERAPY/*MICROBIOLOGY
       English Abstract  Fluconazole/*PHARMACOLOGY/THERAPEUTIC USE  Human
       Immunodiffusion  Microbial Sensitivity Tests  Recurrence  JOURNAL
       ARTICLE

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