Document 0561
 DOCN  M9550561
 TI    Qualitative study of drug resistance in retroviral protease using
       structural modeling and site-directed mutagenesis.
 DT    9505
 AU    Culberson JC; Bush BL; Sardana VV; Department of Molecular Systems,
       Merck Research Laboratories,; West Point, Pennsylvania 19486.
 SO    Methods Enzymol. 1994;241:385-94. Unique Identifier : AIDSLINE
       MED/95157322
 DE    Amino Acid Sequence  Antiviral Agents/CHEMISTRY/*PHARMACOLOGY  Aspartic
       Proteinases/ANTAGONISTS & INHIB/*CHEMISTRY/GENETICS  Binding Sites
       *Computer Simulation  *Drug Resistance, Microbial  HIV
       Protease/CHEMISTRY/GENETICS  HIV Protease
       Inhibitors/CHEMISTRY/PHARMACOLOGY  HIV-1/DRUG EFFECTS/ENZYMOLOGY
       HIV-2/DRUG EFFECTS/ENZYMOLOGY  *Models, Molecular  Molecular Sequence
       Data  Mutagenesis, Site-Directed  Protein Binding  *Protein Conformation
       Retroviridae/*DRUG EFFECTS/GENETICS  Retroviridae Proteins/ANTAGONISTS &
       INHIB/*CHEMISTRY/GENETICS  Software  Substrate Specificity  JOURNAL
       ARTICLE  REVIEW  REVIEW, TUTORIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).