Document 0606
 DOCN  M9550606
 TI    Host response to Sendai virus in mice lacking class II major
       histocompatibility complex glycoproteins.
 DT    9505
 AU    Hou S; Mo XY; Hyland L; Doherty PC; Department of Immunology, St. Jude
       Children's Research Hospital,; Memphis, Tennessee 38105.
 SO    J Virol. 1995 Mar;69(3):1429-34. Unique Identifier : AIDSLINE
       MED/95156566
 AB    The development of Sendai virus-specific cytotoxic T-lymphocyte (CTL)
       effectors and precursors (CTLp) has been compared for mice that are
       homozygous (-/-) for a disruption of the H-2I-Ab class II major
       histocompatibility complex glycoprotein and for normal (+/+) controls.
       The generation of CD8+ CTLp was not diminished in the -/- mice, though
       they failed to make virus-specific immunoglobulin G class antibodies.
       While the cellularity of the regional lymph nodes was decreased, the
       inflammatory process assayed by bronchoalveolar lavage (BAL) of the
       pneumonic lung was not modified, and potent CTL effectors were present
       in BAL populations recovered from both groups at day 10 after infection.
       There was little effect on virus clearance. Production of interleukin-2
       by both freshly isolated BAL inflammatory cells and cultured lymph node
       cells was greatly diminished, though the -/- mice still made substantial
       levels of gamma interferon. However, treating the mice with a single
       dose of a monoclonal antibody to this cytokine, at least some of which
       is made by CD8+ T cells, did not decrease CTLp frequencies. As found
       previously with CD4-depleted H-2b mice, the development of Sendai
       virus-specific CD8+ T-cell-mediated immunity is not compromised by the
       absence of a concurrent class II major histocompatibility
       complex-restricted response.
 DE    Animal  Antibodies, Viral/BIOSYNTHESIS  Cytokines/METABOLISM
       CD4-Positive T-Lymphocytes/IMMUNOLOGY  CD8-Positive
       T-Lymphocytes/*IMMUNOLOGY  Histocompatibility Antigens Class
       II/*IMMUNOLOGY  Immunity, Cellular  Interferon Type II/PHARMACOLOGY
       Lymphocyte Cooperation  Lymphocyte Count  Lymphoid Tissue/CYTOLOGY  Mice
       Mice, Mutant Strains  Parainfluenza/*IMMUNOLOGY  Parainfluenza Virus
       Type 1/*IMMUNOLOGY  Support, Non-U.S. Gov't  Support, U.S. Gov't, P.H.S.
       T-Lymphocytes, Cytotoxic/*IMMUNOLOGY  T-Lymphocytes,
       Helper-Inducer/IMMUNOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).