Document 0613
 DOCN  M9550613
 TI    Prevention of HIV coat protein (gp120) toxicity in cortical cell
       cultures by riluzole.
 DT    9505
 AU    Sindou P; Couratier P; Esclaire F; Yardin C; Bousseau A; Hugon J; Unite
       de Neurobiologie Cellulaire, Faculte de Medecine,; Limoges, France.
 SO    J Neurol Sci. 1994 Nov;126(2):133-7. Unique Identifier : AIDSLINE
       MED/95156087
 AB    Neurological complications observed in HIV-infected patients are very
       frequent. Neocortical lesions include reduced neuronal density due to
       neuronal degeneration. The HIV envelope protein gp120 has potent
       neurotoxic properties in cell cultures blocked either by NMDA
       antagonists or calcium channel antagonists. Moreover, human monocytoid
       cell lines infected by HIV release endogenous toxic factors with
       comparable cellular actions. We have analysed the effects of riluzole, a
       compound reducing the excitatory amino acid release on gp120-induced
       neurotoxicity in primary neuronal cultures. Riluzole, which blocks the
       release of glutamate and aspartate from nerve terminals, prevents
       (10(-7) M) the neuronal degeneration produced by 20 pM of gp120 in
       cortical cell cultures. This result could suggest that toxic factors
       produced by activated macrophages might increase glutamate release, and
       that this may be prevented by riluzole.
 DE    Animal  Cells, Cultured  Cerebral Cortex/CYTOLOGY/*DRUG EFFECTS
       Glutamates/ANTAGONISTS & INHIB  HIV Envelope Protein gp120/*TOXICITY
       HIV-1/METABOLISM  Nerve Degeneration/DRUG EFFECTS  Neurons/DRUG EFFECTS
       Neuroprotective Agents/*PHARMACOLOGY  Peptide Fragments/*TOXICITY  Rats
       Support, Non-U.S. Gov't  Thiazoles/*PHARMACOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).