Document 0614
 DOCN  M9550614
 TI    A neuropathological study of paraparetic rats injected with
       HTLV-I-producing T cells.
 DT    9505
 AU    Mizusawa H; Kushida S; Matsumura M; Tanaka H; Ami Y; Hori M; Kobayashi
       M; Uchida K; Yagami K; Yoshizawa T; et al; Department of Neurology,
       University of Tsukuba, Ibaraki-ken,; Japan.
 SO    J Neurol Sci. 1994 Nov;126(2):101-8. Unique Identifier : AIDSLINE
       MED/95156083
 AB    In order to clarify the pathogenesis of HTLV-I-associated myelopathy or
       tropical spastic paraparesis (HAM/TSP), we injected HTLV-I-producing
       rabbit or human T cells intravenously into WKA and F344 rats. Infection
       was confirmed from increase in the anti-HTLV-I antibody titer and from
       the presence of HTLV-I proviral DNA. Only WKA rats developed hindlimb
       paraparesis 78-124 weeks after the injection. Neuropathological
       examination of 5 rats showed degeneration of the anterolateral and
       posterior funiculi as well as the peripheral nerves, and this
       degeneration was characterized by prominent vacuolation and macrophage
       infiltration. The myelopathy and neuropathy were grossly similar to
       those in human HAM/TSP. Although pathological changes of the spinal cord
       were very mild in 2 paretic rats, and similar lesions were found in the
       spinal cords and peripheral nerves of 2 control WKA rats, the
       myelopathy, radiculoneuropathy, or both in the paretic rats showed
       greater severity than in the controls. The contribution of the aging
       process to the lesions of the spinal cord and peripheral nerve is
       discussed. It appears possible that HTLV-I may accelerate the aging
       process and give rise to paraparesis. The precise role of HTLV-I in the
       pathogenesis of rat paraparesis remains to be elucidated taking the role
       of the aging process of the spinal cord and peripheral nerve into
       account.
 DE    Animal  Brain/PATHOLOGY  Female  HTLV-I/*GROWTH & DEVELOPMENT  Nervous
       System/*PATHOLOGY  Paraparesis, Tropical Spastic/*PATHOLOGY/VIROLOGY
       Peripheral Nerves/PATHOLOGY  Rats  Rats, Inbred F344  Rats, Inbred
       Strains  Spinal Cord/PATHOLOGY  Spinal Nerve Roots/PATHOLOGY  Support,
       Non-U.S. Gov't  T-Lymphocytes/*TRANSPLANTATION/*VIROLOGY  JOURNAL
       ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).