Document 0615
 DOCN  M9550615
 TI    Novel naphthoquinones from Conospermum incurvum.
 DT    9505
 AU    Dai JR; Decosterd LA; Gustafson KR; Cardellina JH 2nd; Gray GN; Boyd MR;
       Laboratory of Drug Discovery Research and Development, National; Cancer
       Institute, Frederick, Maryland 21702-1201.
 SO    J Nat Prod. 1994 Nov;57(11):1511-6. Unique Identifier : AIDSLINE
       MED/95156071
 AB    During the reisolation of the trimeric naphthoquinone derivative
       conocurvone [1] from an extract of the Australian shrub Conospermum
       incurvum, six monomeric naphthoquinones were isolated. These include
       three novel 1,4-naphthoquinone derivatives:
       3-methyl-14,15-dihydro-15-hydroxyteretifolione B [3],
       3-methyl-14,15-dihydro-15-hydroxyteretifolione B methyl ether [4], and
       2,3-dimethyl-6-hydroxy-7-methoxy-1,4-naphthoquinone [5]. In addition,
       the previously reported compounds 3-methylteretifolione B [6],
       3-methylteretifolione B methyl ether [7], and
       8-geranyl-2,7-dihydroxy-3-methyl-1,4-naphthoquinone [8] were isolated
       and identified. The structures of the novel 1,4-naphthoquinones were
       elucidated by spectral methods. While conocurvone [1] is a potent
       inhibitor of HIV-1-induced cell killing, all of the monomeric
       naphthoquinone derivatives were inactive against HIV-1.
 DE    Antiviral Agents/*CHEMISTRY/ISOLATION & PURIF/PHARMACOLOGY  Australia
       Cell Survival/DRUG EFFECTS  Comparative Study  Human  HIV-1/*DRUG
       EFFECTS/PATHOGENICITY  Molecular Structure
       Naphthoquinones/*CHEMISTRY/ISOLATION & PURIF/PHARMACOLOGY  Nuclear
       Magnetic Resonance  Plant Roots  Plants/*CHEMISTRY  Support, Non-U.S.
       Gov't  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).