Document 0617
 DOCN  M9550617
 TI    Detection of cytomegalovirus-matrix protein (pp65) in leukocytes of
       HIV-infected patients with painful peripheral neuropathy.
 DT    9505
 AU    Mastroianni CM; Sebastiani G; Folgori F; Ajassa C; Vullo V; Volpi A;
       Institute of Infectious Diseases, La Sapienza University, Rome,; Italy.
 SO    J Med Virol. 1994 Oct;44(2):172-5. Unique Identifier : AIDSLINE
       MED/95156022
 AB    Painful peripheral neuropathy (PPN) in HIV-infected patients has been
       increasingly associated with cytomegalovirus (CMV) infection at other
       sites. In the last few years, the detection of CMV lower matrix
       phosphoprotein (pp65) antigen in leukocytes has become a major tool in
       the diagnosis of CMV systemic infection in immunocompromised patients.
       In this study, CMV antigen detection was assessed in 13 HIV-infected
       patients with PPN and, as controls, in 82 HIV seropositive patients
       without any evidence of peripheral nerve syndromes (10 with CMV
       retinitis and 72 without CMV end-organ disease). CMV antigenemia was
       found in 10 (76.9%) patients with PPN, in 5 (6.9%) without CMV disease,
       and in all 10 patients (100%) with CMV retinitis. Of the 10 PPN patients
       with CMV antigenemia, only 3 presented with CMV retinitis, while the
       remaining 7 had no clinical evidence of overt CMV infection at other
       sites. CMV pp65-positive cells were also found in three of the four
       cerebrospinal fluid (CSF) samples collected from PPN patients.
       Ganciclovir was effective in improving neurological symptoms in two of
       the four treated patients. The findings suggest that active CMV
       infection may be associated with PPN in HIV infection even in the
       absence of CMV disease at other sites. The detection of CMV-matrix pp65
       antigen in the blood and CSF leukocytes could represent a simple and
       rapid tool of selecting PPN patients for antiviral therapy.
 DE    Adult  Antigens, Viral/BLOOD/CEREBROSPINAL FLUID  AIDS-Related
       Opportunistic Infections/COMPLICATIONS/DIAGNOSIS/  VIROLOGY
       Cytomegalovirus/IMMUNOLOGY/*ISOLATION & PURIF  Cytomegalovirus
       Infections/*COMPLICATIONS/DIAGNOSIS/VIROLOGY  Female  Human  HIV
       Infections/*COMPLICATIONS/*VIROLOGY  Leukocytes/VIROLOGY  Male
       Peripheral Nervous System Diseases/*COMPLICATIONS/DIAGNOSIS/  *VIROLOGY
       Phosphoproteins/BLOOD/CEREBROSPINAL FLUID/*ISOLATION & PURIF  Support,
       Non-U.S. Gov't  Viral Matrix Proteins/BLOOD/CEREBROSPINAL
       FLUID/*ISOLATION &  PURIF  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).