Document 0618
 DOCN  M9550618
 TI    Laboratory study of HIV-1 and HTLV-I/II coinfection.
 DT    9505
 AU    Beilke MA; Greenspan DL; Impey A; Thompson J; Didier PJ; Section of
       Infectious Diseases, Tulane University School of; Medicine, New Orleans,
       LA 70112.
 SO    J Med Virol. 1994 Oct;44(2):132-43. Unique Identifier : AIDSLINE
       MED/95156017
 AB    A Retroviral Coinfection Clinic was established in 1991 at Charity
       Hospital Medical Center of Louisiana to study patients dually infected
       with human immunodeficiency virus (HIV) and human T lymphotropic virus
       (HTLV-I, HTLV-II). Eight patients were evaluated clinically, and by
       immunological and virological studies. Multiple neuromuscular diseases
       were observed, including tropical spastic paraparesis, polymyositis, and
       polyneuropathies. Only one patient developed AIDS. HIV-1 infected
       patients with HTLV-I, but not HTLV-II, coinfection have maintained
       stable CD4 counts, despite the fact that quantitative HIV DNA PCR
       suggests a relatively high copy number. HTLV-I/II antigens were detected
       in lymphocyte cultures from four patients, and lymphoblastoid cell lines
       have been established from two. These results support the contention
       that upregulated HTLV-I/II virus expression and disease manifestations
       occur during coinfection with HIV, sometimes in association with normal
       CD4 counts.
 DE    Adult  Cell Line, Transformed  CD4 Lymphocyte Count  DNA,
       Viral/GENETICS/ISOLATION & PURIF  Female  Human  HIV
       Infections/*COMPLICATIONS/IMMUNOLOGY/VIROLOGY  *HIV-1/GENETICS
       HTLV-I/GENETICS/ISOLATION & PURIF  HTLV-I
       Infections/*COMPLICATIONS/IMMUNOLOGY/VIROLOGY
       HTLV-II/GENETICS/ISOLATION & PURIF  HTLV-II
       Infections/*COMPLICATIONS/IMMUNOLOGY/VIROLOGY  Male  Middle Age
       Polymerase Chain Reaction  Prognosis  Prospective Studies  Support,
       Non-U.S. Gov't  Support, U.S. Gov't, P.H.S.  CLINICAL TRIAL  JOURNAL
       ARTICLE

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