Document 0620
 DOCN  M9550620
 TI    Functional deficiencies in two distinct interferon alpha-producing cell
       populations in peripheral blood mononuclear cells from human
       immunodeficiency virus seropositive patients.
 DT    9505
 AU    Feldman SB; Milone MC; Kloser P; Fitzgerald-Bocarsly P; Graduate School
       of Biomedical Sciences, University of Medicine; and Dentistry of New
       Jersey, Newark.
 SO    J Leukoc Biol. 1995 Feb;57(2):214-20. Unique Identifier : AIDSLINE
       MED/95155887
 AB    Two populations of IFN-alpha producing cells (IPC) were examined to
       determine whether they are coordinately dysregulated in human
       immunodeficiency virus (HIV) disease. IFN-alpha produced in response to
       herpes simplex virus (HSV) and Sendai virus (SV) was measured and the
       frequencies of the IPC were obtained by ELISpot assay. IPC that respond
       to HSV (natural IFN-alpha producing cells) and those responding to SV
       (predominantly monocytes) were present, on average, at 7.6 and 138 per
       10(4) PBMC in healthy controls, respectively. More patients had a
       reduced IFN-alpha response to HSV than to SV, and individual patients
       did not show a decreased response to SV without a decreased response to
       HSV. Neither IPC function was correlated with CD4+ cell levels. We
       conclude that the defects in IFN-alpha production in these two cell
       populations arise independently, possibly due to differences in
       susceptibility to HIV infection or molecular regulation.
 DE    Comparative Study  CD4 Lymphocyte Count  Fibroblasts/VIROLOGY  Herpes
       Simplex/IMMUNOLOGY  Human  HIV Seropositivity/*BLOOD/IMMUNOLOGY/VIROLOGY
       Interferon-alpha/*BIOSYNTHESIS  Leukocytes,
       Mononuclear/IMMUNOLOGY/*METABOLISM/*PHYSIOLOGY  Parainfluenza/IMMUNOLOGY
       Parainfluenza Virus Type 1/METABOLISM  Reference Values
       Simplexvirus/METABOLISM  JOURNAL ARTICLE

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