Document 0622
 DOCN  M9550622
 TI    [Mother-to-infant transmission of hepatitis C virus]
 DT    9505
 AU    Koseki S; Department of Obstetrics and Gynecology, Yokohama City
       University; School of Medicine.
 SO    Nippon Sanka Fujinka Gakkai Zasshi. 1994 Dec;46(12):1322-8. Unique
       Identifier : AIDSLINE MED/95155819
 AB    Anti-HCV antibody was examined in 4,801 pregnant women by using the
       first or second generation radioimmunoassay systems. Antibody positive
       patients were further tested for HCV-RNA by RT-semi nested polymerase
       chain reaction. Anti-HCV antibody was found to be positive in 59 women
       (1.23%) and HCV-RNA in 25 women (0.52%). Fourteen newborn babies born to
       anti-HCV antibody positive mothers were all positive for anti-HCV
       antibody but negative for HCV-RNA at delivery. HCV-RNA was detected in 3
       of 13 children (23.1%) at 3, 5 and 9 months of age, respectively. All of
       their mothers had mild transaminase elevations in the third trimester.
       One of them was positive for both HCV and HIV. Although three mothers
       had HCV-RNA in the milk, their children were still sero-negative for
       HCV-RNA. These results suggest that mother-to-infant transmission of HCV
       may occur at delivery and transaminase elevation in the third trimester
       is one of the risk factors in mother-to-infant transmission of HCV.
 DE    Aminotransferases/ANALYSIS  Delivery  *Disease Transmission, Vertical
       English Abstract  Female  Hepatitis Antibodies/ANALYSIS  Hepatitis
       C/*TRANSMISSION  Hepatitis C Viruses/GENETICS  Human  Infant, Newborn
       Milk, Human/VIROLOGY  Pregnancy  RNA, Viral/ANALYSIS  JOURNAL ARTICLE

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