Document 0644
 DOCN  M9550644
 TI    The progressive outer retinal necrosis syndrome.
 DT    9505
 AU    Holland GN; UCLA School of Medicine, Jules Stein Eye Institute
       90024-7003.
 SO    Int Ophthalmol. 1994;18(3):163-5. Unique Identifier : AIDSLINE
       MED/95154969
 AB    The progressive outer retinal necrosis (PORN) syndrome is a recently
       described clinical variant of necrotizing herpetic retinopathy in
       patients with the acquired immunodeficiency syndrome (AIDS). It is
       caused by varicellazoster virus infection of the retina. Its course and
       clinical features distinguish it from the acute retinal necrosis
       syndrome and CMV retinopathy. Early disease is characterized by
       multifocal deep retinal opacification. Lesions rapidly coalesce and
       progress to total retinal necrosis over a short period of time. Despite
       aggressive therapy with intravenous antivirial drugs, prognosis is poor;
       disease progression and/or recurrence is common, and the majority of
       patients develop no light perception vision. Total retinal detachments
       are common. Prophylaxis against retinal detachment using laser
       retinopexy has not been useful in most cases. PORN syndrome is an
       uncommon, but devastating complication of AIDS.
 DE    AIDS-Related Opportunistic Infections/*COMPLICATIONS/DRUG THERAPY
       Herpes Zoster Ophthalmicus/*COMPLICATIONS/DRUG THERAPY  Human  Prognosis
       Retinal Necrosis Syndrome, Acute/DRUG THERAPY/*ETIOLOGY/PATHOLOGY
       JOURNAL ARTICLE  REVIEW  REVIEW, TUTORIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).