Document 0648
 DOCN  M9550648
 TI    Mathematical modelling of immunotherapy in HIV infection.
 DT    9505
 AU    Dolezal J; Hraba T; Institute of Information Theory and Automation,
       Academy of; Sciences of the Czech Republic, Praha.
 SO    Folia Biol (Praha). 1994;40(4):193-9. Unique Identifier : AIDSLINE
       MED/95154536
 AB    The effect of active or passive immunotherapy on HIV infection was
       simulated using a mathematical model of CD4+ lymphocyte depletion.
       Permanently effective active immunotherapy increased CD4+ lymphocyte
       counts to a steady-state level depending on the intensity of the
       therapy. Active HIV immunization effective for one or more years
       increased CD4+ lymphocyte counts during the treatment period and
       prolonged survival substantially; this prolongation exceeded the time
       interval of therapy duration. Intensive passive immunotherapy by
       anti-HIV antibodies led to a temporary increase of CD4+ lymphocyte
       numbers and an apparent prolongation of survival.
 DE    CD4 Lymphocyte Count  Human  HIV Infections/IMMUNOLOGY/*THERAPY
       *Immunotherapy  Immunotherapy, Adoptive  *Models, Immunological  JOURNAL
       ARTICLE

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