Document 0657
 DOCN  M9550657
 TI    HIV infections in children.
 DT    9505
 AU    Walker AR; Division of General Pediatrics and Adolescent Medicine,
       Johns; Hopkins University School of Medicine, Baltimore, Maryland.
 SO    Emerg Med Clin North Am. 1995 Feb;13(1):147-62. Unique Identifier :
       AIDSLINE MED/95154215
 AB    HIV infection in infants and children who acquire it early in life is
       quite different from HIV infection in adults. The immune deficiency that
       results occurs in an immunologically naive organism, resulting in a
       larger role for common pathogens in causing severe infections. The
       immune deficiency is superimposed on age-related changes in all parts of
       the immune system so that a CD4 count that would be comforting in an
       adult or older child is cause for concern in an infant. Manifestations
       of infection include susceptibility to common and opportunistic
       infection, but growth failure and neurocognitive delays are much more
       significant patterns of disease than in adults. Therapy is clearly
       effective in slowing progression of the disease and, in the case of
       treatment of the pregnant woman, capable of primarily preventing the
       infection. The emergency physician's role in the treatment of children
       with HIV infection includes early identification, management of
       infections and complications, and advocacy for children who are so often
       unable to advocate for themselves.
 DE    AIDS Dementia Complex/DIAGNOSIS/THERAPY  AIDS-Related Opportunistic
       Infections/*COMPLICATIONS/DIAGNOSIS/  THERAPY  Child  Child, Preschool
       Fever/DIAGNOSIS  Human  HIV
       Infections/COMPLICATIONS/*DIAGNOSIS/EPIDEMIOLOGY/*THERAPY
       Immunoglobulins, Intravenous/THERAPEUTIC USE  Immunotherapy, Active
       Infant  Infant, Newborn  Lung Diseases/DIAGNOSIS  Respiratory Tract
       Infections/DIAGNOSIS  Zidovudine/THERAPEUTIC USE  JOURNAL ARTICLE
       REVIEW  REVIEW, TUTORIAL

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