Document 0675
 DOCN  M9550675
 TI    Vitamin, trace element and peroxide status in HIV seropositive patients:
       asymptomatic patients present a severe beta-carotene deficiency.
 DT    9505
 AU    Sappey C; Leclercq P; Coudray C; Faure P; Micoud M; Favier A; Groupe de
       Recherche et d'etude sur les Pathologies Oxydatives; (GREPO), Faculte de
       Medecine et de Pharmacie, La Tronche,; France.
 SO    Clin Chim Acta. 1994 Oct 14;230(1):35-42. Unique Identifier : AIDSLINE
       MED/95153878
 AB    We have investigated whether nutritional status and peroxidation process
       are associated with the degree of development of HIV infection. This was
       done by measuring the status of vitamins (E, A and beta-carotene), of
       antioxidant trace elements (zinc, selenium) and lipid peroxide levels
       (lipid hydroperoxides and thiobarbituric acid reactants) in
       HIV-seropositive patients at CDC II and CDC IV stages and in comparison
       with normal subjects. There was a decrease in vitamin and trace element
       levels related to the severity of disease. The most dramatic decrease,
       however, was seen for carotenoids (0.94 +/- 0.46 mumol/l) and
       beta-carotene (0.24 +/- 0.14 mumol/l vs. 0.56 +/- 0.29 mumol/l) whose
       stage II levels were only half the normal value. Paradoxically, lipid
       peroxidation was higher at stage II than at stage IV. This can be
       attributed to an overproduction of oxygen radicals by polymorphonuclears
       in stage II. This deficiency in antioxidant status, often found in
       patients suffering from peroxidative diseases, may have important
       consequences on cellular immunity. Furthermore, the concomitant
       overproduction of free radicals may also affect HIV multiplication.
 DE    Adult  Antioxidants/METABOLISM  Carotene/*DEFICIENCY  Glutathione
       Peroxidase/BLOOD  Human  HIV Seropositivity/*BLOOD  Lipid
       Peroxides/*BLOOD  Male  Nutritional Status  Support, Non-U.S. Gov't
       Thiobarbituric Acid Reactive Substances/METABOLISM  Trace
       Elements/*BLOOD  Vitamin A/BLOOD  Vitamins/*BLOOD  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
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