Document 0682
 DOCN  M9550682
 TI    Drug resistance in viruses.
 DT    9505
 AU    Richman DD; University of California San Diego, Dept of Pathology, La
       Jolla; 92093-0679.
 SO    Trends Microbiol. 1994 Oct;2(10):401-7. Unique Identifier : AIDSLINE
       MED/95153053
 AB    The mechanisms of action of antiviral drugs and of drug resistance are
       known in remarkable detail, partly because X-ray crystallographic
       structures are known for many target viral proteins. Resistance usually
       involves amino acid substitutions in the target protein that prevent
       drug binding or prevent an enzyme from accepting the drug as a
       substrate. This information allows more effective use of available drugs
       and aids the development of new drugs.
 DE    Alphaherpesvirinae/*DRUG EFFECTS  Antiviral Agents/*PHARMACOLOGY  Drug
       Resistance, Microbial  HIV/*DRUG EFFECTS  Picornaviridae/*DRUG EFFECTS
       Support, U.S. Gov't, Non-P.H.S.  Support, U.S. Gov't, P.H.S.  JOURNAL
       ARTICLE  REVIEW  REVIEW, TUTORIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).