Document 0688
 DOCN  M9550688
 TI    Responses of lymphocytes to Epstein-Barr virus in patients with primary
       immunodeficiencies.
 DT    9505
 AU    Kondo N; Inoue R; Orii T; Department of Pediatrics, Gifu University
       School of Medicine,; Japan.
 SO    J Investig Allergol Clin Immunol. 1994 Jul-Aug;4(4):182-4. Unique
       Identifier : AIDSLINE MED/95152872
 AB    Several reports have demonstrated that the responses of B-cells to
       Epstein-Barr virus (EBV) are variable in common variable
       immunodeficiency (CVID). In this study in patients with selected primary
       immunodeficiencies, i.e., Bloom's syndrome, Wiskott-Aldrich syndrome or
       IgA deficiency, the responses of peripheral blood mononuclear cells
       (PBMCs) to EBV were investigated. In the two patients with Bloom's
       syndrome, PBMCs stimulated with EBV showed decreased proliferation and
       immunoglobulin production, suggesting a mild abnormality of B-cells. In
       patients with Wiskott-Aldrich syndrome, the responses were variable. In
       the patient with IgA deficiency, PBMCs responded normally to EBV in
       proliferation, whereas PBMCs responded poorly to EBV in IgA production,
       suggesting an abnormality only in the IgA production mechanism.
 DE    B-Lymphocytes/IMMUNOLOGY  Bloom Syndrome/IMMUNOLOGY  Child  Child,
       Preschool  Herpesvirus 4, Human/*IMMUNOLOGY  Human  IgA
       Deficiency/IMMUNOLOGY  Immunoglobulins/BIOSYNTHESIS  Immunologic
       Deficiency Syndromes/*IMMUNOLOGY  In Vitro  Lymphocyte Transformation
       Lymphocytes/*IMMUNOLOGY  T-Lymphocytes/IMMUNOLOGY  Wiskott-Aldrich
       Syndrome/IMMUNOLOGY  JOURNAL ARTICLE

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