Document 0695
 DOCN  M9550695
 TI    Complement activation and hemodynamic changes following intravenous
       administration of phosphorothioate oligonucleotides in the monkey.
 DT    9505
 AU    Galbraith WM; Hobson WC; Giclas PC; Schechter PJ; Agrawal S; APD
       Company, Arlington, Virginia 22209.
 SO    Antisense Res Dev. 1994 Fall;4(3):201-6. Unique Identifier : AIDSLINE
       MED/95152265
 AB    Rapid intravenous infusion of GEM 91, a 25-mer phosphorothioate
       oligonucleotide complementary to the gag site of HIV, in the monkey
       produces transient decreases in peripheral total WBC and neutrophil
       counts, hemoconcentration, and a brief increase followed by a prolonged
       decrease in arterial blood pressure. These changes are preceded by and
       are likely mediated by activation of C5 complement. These effects are
       dose and infusion rate dependent and can be avoided by administering GEM
       91 by slow intravenous infusion. Similar hemodynamic effects are
       produced with rapid intravenous infusion of other phosphorothioate
       oligonucleotides varying in length from 20- to 33-mer, and are,
       therefore, not sequence specific but a property of this chemical
       structure.
 DE    Animal  Base Sequence  Complement Activation/*DRUG EFFECTS  Female
       Hemodynamics/*DRUG EFFECTS  Infusions, Intravenous  Macaca mulatta  Male
       Molecular Sequence Data  Oligonucleotides/*PHARMACOLOGY
       Thionucleotides/*PHARMACOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).