Document 0697
 DOCN  M9550697
 TI    [Changes in the immune status in patients with basal cell carcinoma of
       the eyelids of various TNM stages]
 DT    9505
 AU    Sivkova N; Grigorov L; Kreissig I; Universitats-Augenklinik,
       Medizinische Universitat Plovdiv.
 SO    Ophthalmologe. 1994 Dec;91(6):820-3. Unique Identifier : AIDSLINE
       MED/95152210
 AB    Various lymphocyte populations/subpopulations--Leu-4+ (CD3+), Leu-2+
       (CD8+), CD4+/CD8+ ratio, Leu-14+ (CD22+), Leu-M5+ and HLA-DR+--were
       studied in 104 patients with basal cell carcinoma (BCC) of the eyelid in
       different TNM stages by Coulter EPICS flow cytometry preoperatively. For
       comparison, an age-matched control group of 60 clinically healthy
       individuals (30 male and 30 female) was used. The mean percentage of
       CD4+ T-lymphocytes was significantly decreased in T3N0M0 and T4N0M0
       stages. In all TNM stages, especially in T3N0M0 and T4N0M0, the CD8+
       T-lymphocyte subpopulation was significantly larger than in the control
       group. In all TNM stages the CD4+/CD8+ ratio was significantly lower
       than that of the control group. The degree of immune imbalance
       correlated directly with tumor size. The immunosuppression may be one
       factor in the development of BCC of the eyelid. Age- or genetic-related
       depression of cell-mediated immunity and increased exposure to
       carcinogenic agents, especially UV light, may play a part.
 DE    Adolescence  Adult  Aged  Aged, 80 and over  Carcinoma, Basal
       Cell/*IMMUNOLOGY/PATHOLOGY  CD4-CD8 Ratio  English Abstract  Eyelid
       Neoplasms/*IMMUNOLOGY/PATHOLOGY  Female  Human  Male  Middle Age
       Neoplasm Staging  T-Lymphocyte Subsets/*IMMUNOLOGY  JOURNAL ARTICLE

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