Document 0699
 DOCN  M9550699
 TI    T cell abnormalities in mixed connective tissue disease complicated with
       Klinefelter's syndrome.
 DT    9505
 AU    Ishihara K; Yoshimura M; Nakao H; Kanakura Y; Kanayama Y; Matsuzawa Y;
       Second Department of Internal Medicine, Osaka University Medical;
       School, Suita.
 SO    Intern Med. 1994 Nov;33(11):714-7. Unique Identifier : AIDSLINE
       MED/95152159
 AB    We report a 28-year-old Japanese with Klinefelter's syndrome who
       developed mixed connective disease (MCTD) and Sjogren syndrome.
       Previously being well, he presented with Raynaud's phenomenon, dry eye,
       fever and polyarthralgia. Clinical examinations revealed anti-nRNP
       autoantibody, leukopenia and lung fibrosis. Then he was found to have
       Klinefelter's syndrome. Flow cytometric analysis showed a relative
       increase of peripheral CD8+ T lymphocytes carrying either HLA-DR or
       CD57. Lymphocyte IL-2 production induced in vitro by concanavalin A was
       decreased. Such T cell abnormalities may be implicated in the
       development of autoimmune disease in Klinefelter's syndrome.
 DE    Adult  Antigens, CD/IMMUNOLOGY  Case Report  CD8-Positive
       T-Lymphocytes/*IMMUNOLOGY  Flow Cytometry  Human  HLA-DR
       Antigens/IMMUNOLOGY  Klinefelter's Syndrome/*COMPLICATIONS/IMMUNOLOGY
       Lymphocyte Transformation/IMMUNOLOGY  Male  Mixed Connective Tissue
       Disease/*COMPLICATIONS/IMMUNOLOGY  Sjogren's
       Syndrome/COMPLICATIONS/IMMUNOLOGY  T-Lymphocyte Subsets/*IMMUNOLOGY
       JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).