Document 0705
 DOCN  M9550705
 TI    Ultrastructural correlation between follicular dendritic cells and the
       frequency of virus-like particles during the lymph nodes reaction of
       SIV/HIV 2 infected cynomolgus monkeys.
 DT    9505
 AU    Mandache E; Biberfeld P; V. Babes Institute, Bucharest, Romania.
 SO    Rom J Morphol Embryol. 1993 Jul-Dec;39(3-4):99-105. Unique Identifier :
       AIDSLINE MED/95152040
 AB    Lymph nodes from 18 SIV/HIV2 infected monkeys developing a severe
       AIDS-like disease were studied by electron microscopy. The lesions were
       correlated with the histopathologic staining and the anti-SIVp28
       immunostaining. The investigation of follicular dendritic cells (FDC)
       and associated retroviral particles was focused on the light zones of
       germinal centres during the follicular hyperplasia, fragmentation
       atrophy and depletion. FDCs were mostly developed in the first two
       stages, while the highest amount of retroviruses was found in the two
       middle stages. During the last stage of follicular depletion FDCs were
       still present but deprived of dendrites and no viral particles were seen
       around. Associated lesions were small haemorrhages, binucleated FDCs,
       viral phagocytosis by macrophages and reticular paracrystalline
       inclusions.
 DE    Acquired Immunodeficiency Syndrome/IMMUNOLOGY/*PATHOLOGY/VIROLOGY
       Animal  Comparative Study  Dendritic Cells/ULTRASTRUCTURE
       HIV-2/*ISOLATION & PURIF  Lymph Nodes/*IMMUNOLOGY  Macaca
       fascicularis/*ANATOMY & HISTOLOGY  Simian Acquired Immunodeficiency
       Syndrome/IMMUNOLOGY/*PATHOLOGY/  VIROLOGY  SIV/*ISOLATION & PURIF
       JOURNAL ARTICLE

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