Document 0718
 DOCN  M9550718
 TI    High cumulative incidence of genital herpes amongst HIV-1 seropositive
       heterosexuals in south London.
 DT    9505
 AU    O'Farrell N; Tovey SJ; Lloyd Clinic, Guy's Hospital, London, UK.
 SO    Int J STD AIDS. 1994 Nov-Dec;5(6):415-8. Unique Identifier : AIDSLINE
       MED/95151864
 AB    The cumulative incidence of sexually transmitted diseases (STD) in a
       cohort of 51 (35 female, 16 male) HIV-1 seropositive STD clinic
       attenders who had acquired HIV-1 infection via heterosexual transmission
       was investigated through a retrospective review of the case notes. The
       women were followed up for a mean 11.6 months and the men for 18 months.
       Thirty-one (88%) of the women and 13 (81%) of the men were of
       sub-Saharan African origin. Approximately half of the subjects were
       first diagnosed as HIV-1 positive with CD4 counts < 200 x 10(6)/1 and a
       quarter with CD4 counts < 50 x 10(6)/1. STDs detected in women were:
       genital herpes 15 (43%), candida 12 (34%), bacterial vaginosis 9 (25%),
       and in men: genital herpes 6 (38%), non-gonococcal urethritis 4 (25%).
       No cases of gonorrhoea were detected. At the time of first diagnosis of
       genital herpes at the clinic, the mean CD4 count in women was 275 x
       10(6)/1 and in men 285 x 10(6)/1. Genital herpes was the AIDS defining
       diagnosis in 3 of the women. The recognized risk of HIV transmission via
       genital lesions should be stressed in HIV-1 positive subjects with
       genital herpes. The incidence of other STD was low--both knowledge of
       HIV status and safer sex counselling may limit unsafe sexual behaviour
       and should be evaluated further as a strategy for limiting the spread of
       HIV-1 infection.
 DE    Female  Follow-Up Studies  Herpes Genitalis/*EPIDEMIOLOGY  Human  HIV
       Seropositivity/*COMPLICATIONS  *HIV-1  London/EPIDEMIOLOGY  Male  Sex
       Behavior  JOURNAL ARTICLE

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