Document 0720
 DOCN  M9550720
 TI    Bacterial vaginosis in a district genitourinary medicine department:
       significance of vaginal microbiology and anaerobes.
 DT    9505
 AU    Saidi SA; Mandal D; Curless E; Department of Genito-urinary Medicine,
       Bolton General Hospital,; Lancs, UK.
 SO    Int J STD AIDS. 1994 Nov-Dec;5(6):405-8. Unique Identifier : AIDSLINE
       MED/95151862
 AB    The aim of this study was to correlate the significance of vaginal
       microbiology, in particular its anaerobic component, to the presence of
       bacterial vaginosis (BV), and to review the clinical criteria used in
       the diagnosis of this condition. Ninety-two female patients who received
       routine STD screening were studied. After routine history, presence and
       character of vaginal discharge and vaginal pH were noted, an amine test
       performed, and a wet stain observed microscopically. Routine Gram stain
       smears and cultures were prepared. BV was diagnosed clinically in 28
       (30%) of our sample, and Gardnerella vaginalis was cultured in 41
       patients (45%). Both clue cells and anaerobes were closely associated
       with each other and both mutually exclusive with the presence of
       lactobacilli on Gram stain (P < 0.001). BV was found to be strongly
       associated with the presence of clue cells on the wet film, anaerobes
       and G. vaginalis. In conclusion, bacterial vaginosis is not only
       strongly associated with the presence of G. vaginalis in the vaginal
       flora, but more strongly with the presence of anaerobes. The study
       suggests that the microaerophile G. vaginalis is a commensal organism in
       a significant proportion of sexually active women. If the aerobic status
       of the healthy vagina is disrupted, anaerobes (including Gardnerella)
       will flourish, producing the clinical picture of bacterial vaginosis.
 DE    Bacteria, Anaerobic/*ISOLATION & PURIF  Female  *Gardnerella
       vaginalis/ISOLATION & PURIF  Human  Vagina/*MICROBIOLOGY  Vaginosis,
       Bacterial/*DIAGNOSIS  JOURNAL ARTICLE

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