Document 0734
 DOCN  M9550734
 TI    [Immune evaluations in cancer patients after colorectal resection]
 DT    9505
 AU    Losacco T; De Leo G; Punzo C; Pellegrino NM; Neri V; D'Eredita G; Di
       Ciaula G; Pitzalis MV; Istituto di Semeiotica Chirurgica, Universita
       degli Studi di; Bari.
 SO    G Chir. 1994 Oct;15(10):429-32. Unique Identifier : AIDSLINE
       MED/95151476
 AB    The authors report a protocol of immunomodulation and monitoring of the
       intestinal function in coloresected patients using fermented milk
       (yoghurt). Intestinal immunity was evaluated with respect to CD4+ cells
       armed with secretory intestine-derived IgA, and to CD8+ cells armed with
       IgG aiming to an additional effect in the host protection against
       Gram-negative strains, such as Salmonella typhi, whose particularly high
       incidence in Apulia accounts for an increased immunitary activity. Ten
       patients (six females, four males), age ranging from 44 to 85 years, who
       underwent surgery between 1989 and 1992, each of whom had been
       prescribed a daily ration of 500 gr skimmed yoghurt for one month, were
       observed. The authors suggest that yoghurt may determine a higher
       release of gamma-IFN with activation of CD4+ and CD8+ cells. The
       Lactobacillus stimulation of the B lymphocytes of the Peyer plates seems
       to induce an increased production of secretory IgA that bind to the CD4+
       surface, and of IgG (as an anamnestic response to challenge with yoghurt
       lactobacilli). Coloresected patients show an immunitary deficiency
       related to the Gram+ bacterial flora reduction and consequently a
       decrease in the physiological stimuli. Although these date concern a
       limited sample, the authors stress the importance of the restoration of
       bacterial flora in coloresected patients.
 DE    Aged  Aged, 80 and over  Colectomy  Colorectal
       Neoplasms/*IMMUNOLOGY/SURGERY  CD4-CD8 Ratio  English Abstract  Female
       Human  Male  Middle Age  Postoperative Care  Postoperative Period
       Rectum/SURGERY  Time Factors  Yogurt  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).