Document 0739
 DOCN  M9550739
 TI    An animal model for antilentiviral therapy: effect of zidovudine on
       viral load during acute infection after exposure of macaques to simian
       immunodeficiency virus.
 DT    9505
 AU    Le Grand R; Clayette P; Noack O; Vaslin B; Theodoro F; Michel G; Roques
       P; Dormont D; Laboratoire de Neuropathologie Experimentale et
       Neurovirologie,; Centre de Recherches du Service de Sante des Armees,;
       Fontenay-aux-Roses, France.
 SO    AIDS Res Hum Retroviruses. 1994 Oct;10(10):1279-87. Unique Identifier :
       AIDSLINE MED/95151365
 AB    We analyzed the kinetics of the virological and immunological events
       that occurred in four AZT-treated cynomolgus macaques during the acute
       infection that followed their exposure to the simian immunodeficiency
       virus (SIVmac251) grown on monkey PBMCs in a cell-free stock solution.
       These events included changes in the CD4+ and CD8+ T lymphocyte subsets,
       p27 antigenemia, infectious serum virus, and cell-associated virus
       loads. The kinetics of these changes proved strikingly similar to those
       reported in human HIV-1 infection. Four other SIV-exposed macaques were
       treated with placebo instead of AZT. We demonstrated that AZT does not
       prevent SIV infection, even when administered before SIV inoculation.
       However, the peaks of p27 antigenemia and of serum and cellular viremia
       were significantly smaller and occurred significantly later in the
       monkeys given AZT than in those given placebo.
 DE    Acquired Immunodeficiency Syndrome/DRUG THERAPY/IMMUNOLOGY/  VIROLOGY
       Animal  Antibodies, Viral/BLOOD  Comparative Study  CD4-Positive
       T-Lymphocytes/IMMUNOLOGY  CD8-Positive T-Lymphocytes/IMMUNOLOGY  Human
       HIV-1/DRUG EFFECTS  Macaca fascicularis  Simian Acquired
       Immunodeficiency Syndrome/*DRUG THERAPY/  IMMUNOLOGY/VIROLOGY  Support,
       Non-U.S. Gov't  SIV/DRUG EFFECTS/ISOLATION & PURIF/*PHYSIOLOGY
       T-Lymphocyte Subsets/IMMUNOLOGY  Virion/ISOLATION & PURIF
       Zidovudine/*THERAPEUTIC USE  JOURNAL ARTICLE

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