Document 0748
 DOCN  M9550748
 TI    Interleukin 10 blocks HIV replication in macrophages by inhibiting the
       autocrine loop of tumor necrosis factor alpha and interleukin 6
       induction of virus.
 DT    9505
 AU    Weissman D; Poli G; Fauci AS; Laboratory of Immunoregulation, National
       Institutes of Allergy; and Infectious Diseases, National Institutes of
       Health, Bethesda,; Maryland 20892.
 SO    AIDS Res Hum Retroviruses. 1994 Oct;10(10):1199-206. Unique Identifier :
       AIDSLINE MED/95151356
 AB    Human interleukin 10 is a pleiotropic cytokine capable of suppressing
       cytokine production from macrophages and T cells; in addition, it exerts
       complex regulatory effects on CD8+ T cells, natural killer cells,
       vascular endothelial cells, and B lymphocytes. Levels of IL-10 are
       elevated in HIV-infected individuals, suggesting that this cytokine may
       play a role in the suppression of T cell and monocyte/macrophage
       function typical of HIV disease. In this article, IL-10 blocked
       HIV-induced tumor necrosis factor alpha and interleukin 6 secretion and
       inhibited HIV replication in monocyte-derived macrophages (MDMs). The
       inhibition by IL-10 was correlated with a block in endogenous TNF-alpha
       and IL-6 secretion from HIV-infected MDMs.
 DE    Antiviral Agents/*PHARMACOLOGY  B-Lymphocytes/IMMUNOLOGY/VIROLOGY
       Cells, Cultured  Dose-Response Relationship, Drug  Fluorescent Antibody
       Technique  Human  HIV/DRUG EFFECTS/*PHYSIOLOGY  HIV
       Infections/IMMUNOLOGY  Interleukin-10/*PHARMACOLOGY
       Interleukin-6/ANTAGONISTS & INHIB/*BIOSYNTHESIS  Kinetics
       Macrophages/DRUG EFFECTS/*IMMUNOLOGY/*VIROLOGY
       Monocytes/IMMUNOLOGY/VIROLOGY  T-Lymphocytes/IMMUNOLOGY/VIROLOGY  Time
       Factors  Tumor Necrosis Factor/ANTAGONISTS & INHIB/*BIOSYNTHESIS  Viral
       Proteins/BIOSYNTHESIS  Virus Replication/*DRUG EFFECTS  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).