Document 0752
 DOCN  M9550752
 TI    Multiple metachronous skin squamous cell carcinomas and
       epidermodysplasia verruciformis in the head region: a human papilloma
       virus-associated disease.
 DT    9505
 AU    Weber BP; Fierlbeck G; Kempf HG; Department of Otorhinolaryngology,
       Medizinische Hochschule; Hannover, Germany.
 SO    Eur Arch Otorhinolaryngol. 1994;251(6):342-6. Unique Identifier :
       AIDSLINE MED/95151323
 AB    Data from a young adult man with epidermodysplasia verruciformis (EV)
       and multiple metachronous spinaliomas in the head and neck region are
       presented. Diagnosis of this rare, human papilloma virus
       (HPV)-associated disease was based on: (1) Typical skin lesions,
       including viral warts, verruca plana-type lesions and pityriasis
       versicilor; (2) typical histological features, including foamy giant
       keratinocytes; (3) evidence of HPV 5, 8 and 20 in pityriasis
       versicilor-like lesions; (4) a cellular immunodeficiency due to a
       relative T-helper-cell deficit. No specific treatment of EV is known, so
       that therapy concentrates on early removal of spinaliomas and treatment
       of intercurrent infections. Since EV patients have numerous benign skin
       lesions and frequently develop metastatic and non-metastatic carcinomas,
       molecular changes of HPV during carcinogenesis can be studied.
 DE    Adult  Carcinoma, Squamous Cell/COMPLICATIONS/*DIAGNOSIS/THERAPY/
       VIROLOGY  Case Report  Epidermodysplasia
       Verruciformis/COMPLICATIONS/*DIAGNOSIS/THERAPY/  VIROLOGY  Human  Male
       Neoplasms, Second Primary/COMPLICATIONS/*DIAGNOSIS/THERAPY/  VIROLOGY
       Papillomavirus, Human/*ISOLATION & PURIF  Papovaviridae
       Infections/COMPLICATIONS/*DIAGNOSIS/VIROLOGY  *Scalp  Skin
       Neoplasms/COMPLICATIONS/*DIAGNOSIS/THERAPY/VIROLOGY  Tumor Virus
       Infections/COMPLICATIONS/*DIAGNOSIS/VIROLOGY  JOURNAL ARTICLE  REVIEW
       REVIEW LITERATURE

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