Document 0765
 DOCN  M9550765
 TI    HIV-2-infected patients survive longer than HIV-1-infected patients.
 DT    9505
 AU    Whittle H; Morris J; Todd J; Corrah T; Sabally S; Bangali J; Ngom PT;
       Rolfe M; Wilkins A; Medical Research Council Laboratories, Banjul, The
       Gambia, West; Africa.
 SO    AIDS. 1994 Nov;8(11):1617-20. Unique Identifier : AIDSLINE MED/95151241
 AB    OBJECTIVE: To compare survival of patients infected with HIV-1 and
       HIV-2. DESIGN: Longitudinal follow-up of 175 HIV-1- and 294
       HIV-2-infected patients identified in, or referred to a hospital in The
       Gambia. METHODS: Survival analysis methods were used and the death rate
       ratios for HIV-2 relative to HIV-1 patients were estimated using
       proportional hazard regression models that allowed for age, sex and
       clinical or immunological features. RESULTS: The overall death rate
       ratio for HIV-2 relative to HIV-1 was 0.67 [95% confidence interval
       (CI), 0.49-0.91] when adjusted for age, sex and World Health
       Organization Bangui clinical classification. When allowing for age, sex
       and three strata of CD4+ count, the rate ratio was 0.64 (95% CI,
       0.43-0.94), and for three strata of beta 2-microglobulin levels 0.60
       (95% CI, 0.42-0.84). CONCLUSION: Mortality rate in HIV-2-infected
       patients is approximately two-thirds of that for HIV-1-infected
       patients.
 DE    Acquired Immunodeficiency Syndrome/*MORTALITY/*VIROLOGY  Adult
       Comparative Study  Female  Human  HIV Infections/*MORTALITY/*VIROLOGY
       *HIV-1  *HIV-2  Male  Probability  Support, Non-U.S. Gov't  Survival
       Analysis  Survival Rate  CLINICAL TRIAL  CONTROLLED CLINICAL TRIAL
       JOURNAL ARTICLE

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