Document 0781
 DOCN  M9550781
 TI    Effect of low dose radiation on intracellular calcium and protein kinase
       C in lymphocytes.
 DT    9505
 AU    Liu SZ; Su X; Han ZB; Zhang YC; Qi J; MPH Radiobiology Research Unit,
       Norman Bethune University of; Medical Sciences, Changchun, China.
 SO    Biomed Environ Sci. 1994 Sep;7(3):284-91. Unique Identifier : AIDSLINE
       MED/95151191
 AB    It is first reported in the present paper that whole-body irradiation
       (WBI) with low dose X-rays could increase intracellular calcium ions
       ([Ca2+]i) and stimulate protein kinase C (PKC) activity of mouse
       lymphocytes. Following WBI of male Kunming mice with 75 mGy X-rays at a
       dose rate of 12.5 mGy/min the mobilization of [Ca2+]i with Con A in CD4+
       and CD8+ Cells in the thymus and spleen was potentiated and the
       amplitude of [Ca2+]i mobilization in thymocytes in response to anti-CD3
       monoclonal antibody increased with time from 4 to 24 h following low
       dose radiation. The PKC activity in the homogenate of spleen was
       markedly stimulated 12 h after WBI with 75 mGy, reaching its peak value
       at 24-48 h and coming down to lower than normal on day 7. However, the
       PKC activity in the separated T lymphocytes reached its peak value at 12
       h and that in the B lymphocytes reached its peak value on day 4, both
       coming down to below control on day 7. The implications of this
       facilitation of signal transduction in T lymphocytes in the mechanism of
       immunoenhancement after low dose radiation were discussed.
 DE    Animal  Calcium/*METABOLISM  Concanavalin A/PHARMACOLOGY  CD4-Positive
       T-Lymphocytes/*RADIATION EFFECTS  CD8-Positive T-Lymphocytes/*RADIATION
       EFFECTS  In Vitro  Male  Mice  Protein Kinase C/*METABOLISM  Second
       Messenger Systems  Spleen/IMMUNOLOGY/RADIATION EFFECTS  Thymus
       Gland/IMMUNOLOGY/RADIATION EFFECTS  JOURNAL ARTICLE

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