Document 0783
 DOCN  M9550783
 TI    The Th1-Th2 hypothesis of HIV infection: new insights.
 DT    9505
 AU    Clerici M; Shearer GM; Cattedra di Immunologia, Universita degli Studi,
       Milano, Italy.
 SO    Immunol Today. 1994 Dec;15(12):575-81. Unique Identifier : AIDSLINE
       MED/95151146
 AB    In their earlier, much quoted, viewpoint article, Mario Clerici and Gene
       Shearer examined the role of T helper 1 (Th1)- and Th2-type responses in
       immune dysregulation associated with human immunodeficiency virus (HIV)
       infection. In this article, they consider the complications of a Th1-Th2
       model raised by the nomenclature, discuss the issue of cytokine
       production by non-T cells, and compare data obtained from T-cell clones
       with heterogeneous populations of leukocytes from patients. They define
       Th-cell responses and cytokine profiles as 'type 1' and 'type 2', and
       reemphasize the importance of strong cellular immune responses, along
       with the cytokines that augment and maintain such responses, in
       protective immunity against HIV infection and AIDS progression. Finally,
       they present a model of activation-induced, cytokine-modulated,
       programmed cell death as a major factor in the pathogenesis of HIV
       infection and AIDS.
 DE    Apoptosis  Cytokines/PHYSIOLOGY  Human  HIV
       Infections/*IMMUNOLOGY/THERAPY  Models, Biological  Support, Non-U.S.
       Gov't  Th1 Cells/*PHYSIOLOGY  Th2 Cells/*PHYSIOLOGY  JOURNAL ARTICLE
       REVIEW  REVIEW, TUTORIAL

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       protected by Copyright Law (Title 17, U.S.Code).