Document 0798
 DOCN  M9550798
 TI    Apoptosis in HIV infection: protective role of IL-2.
 DT    9505
 AU    Cordiali Fei P; Solmone M; Viora M; Vanacore P; Pugliese O; Giglio A;
       Caprilli F; Ameglio F; Laboratory of Clinical Pathology, Istituto San
       Gallicano, Roma,; Italy.
 SO    J Biol Regul Homeost Agents. 1994 Apr-Jun;8(2):60-4. Unique Identifier :
       AIDSLINE MED/95168000
 AB    Peripheral blood mononuclear cells from HIV-infected subjects have been
       demonstrated by different methods to die by apoptosis after short time
       in culture. In the present study the percentages of apoptotic cells have
       been measured by propidium iodide staining and flow cytometry in PBMC
       from healthy controls (15) and HIV-infected subjects with asymptomatic
       (10) or advanced (15) disease, with or without anti-viral treatment. The
       percentage of apoptosis significantly correlated with clinical stage
       (CDCII: 15.85% +/- 9.17, CDCIV: 22.6% +/- 5.97, P < 0.001) and the
       CD4/CD8 CD3 cell ratio. R = -0.57, P = 0.012), while no differences were
       found in relation to AZT therapy. By adding IL-2 to the cultures the
       percentages of apoptosis of PBMC from HIV-infected patients were
       significantly reduced in all experiments.
 DE    Apoptosis/*IMMUNOLOGY  DNA/BLOOD  Flow Cytometry  Human  HIV
       Infections/*BLOOD/*IMMUNOLOGY  *HIV-1  In Vitro
       Interleukin-2/*PHARMACOLOGY  Leukocytes,
       Mononuclear/*IMMUNOLOGY/METABOLISM/*PATHOLOGY  JOURNAL ARTICLE

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