Document 0826
 DOCN  M9550826
 TI    Development of leukemia in mice transgenic for the tax gene of human
       T-cell leukemia virus type I.
 DT    9505
 AU    Grossman WJ; Kimata JT; Wong FH; Zutter M; Ley TJ; Ratner L; Department
       of Medicine, Washington University School of Medicine,; St. Louis, MO
       63110.
 SO    Proc Natl Acad Sci U S A. 1995 Feb 14;92(4):1057-61. Unique Identifier :
       AIDSLINE MED/95166767
 AB    The human T-cell leukemia virus type I Tax protein trans-activates
       several cellular genes implicated in T-cell replication and activation.
       To investigate its leukemogenic potential, Tax was targeted to the
       mature T-lymphocyte compartment in transgenic mice by using the human
       granzyme B promoter. These mice developed large granular lymphocytic
       leukemia, demonstrating that expression of Tax in the lymphocyte
       compartment is sufficient for the development of leukemia. Furthermore,
       these observations suggest that human T-cell leukemia virus infection
       may be involved in the development of large granular lymphocytic
       leukemia.
 DE    Animal  Base Sequence  Cell Compartmentation  DNA Probes  *Genes, pX
       Human  HTLV-I/*GENETICS  Leukemia, Experimental/*GENETICS/VIROLOGY  Male
       Mice  Mice, Transgenic  Molecular Sequence Data  Promoter Regions
       (Genetics)  Serine Proteinases/GENETICS  Support, Non-U.S. Gov't
       Support, U.S. Gov't, P.H.S.  T-Lymphocytes/METABOLISM  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).