Document 0829
 DOCN  M9550829
 TI    Bacillus Calmette-Guerin complications in children born to
       HIV-1-infected women with a review of the literature.
 DT    9505
 AU    O'Brien KL; Ruff AJ; Louis MA; Desormeaux J; Joseph DJ; McBrien M;
       Coberly J; Boulos R; Halsey NA; Department of International Health,
       School of Hygiene and Public; Health, Johns Hopkins University,
       Baltimore, MD.
 SO    Pediatrics. 1995 Mar;95(3):414-8. Unique Identifier : AIDSLINE
       MED/95166595
 AB    OBJECTIVE. To compare the risk of complications following Bacillus
       Calmette-Guerin (BCG) vaccination among children by maternal and infant
       HIV-1 infection status as part of an investigation of an outbreak of BCG
       complications. METHODS. A nonconcurrent cohort study of BCG
       complications among 125 infants born to HIV-1 seropositive and 166
       infants born to HIV-1 seronegative mothers was conducted in Cite Soleil,
       Haiti. Infants were examined at regular intervals until 15 months of
       age, and complications from BCG were documented. An investigation of BCG
       vaccination practices was conducted. RESULTS. Mild or moderate
       complications occurred among 16 of 166 (9.6%) infants born to HIV-1
       seronegative mothers compared with 4 of 13 HIV-1-infected infants
       (30.8%, P = .04) and 10 of 75 (13.3%, P = .39) uninfected infants born
       to HIV-1-infected mothers. No serious complications were noted. The
       outbreak of complications was associated with administration of 2.0 to
       2.5 times the recommended dose of BCG vaccine. CONCLUSIONS. This and
       five other cohort studies indicate that there may be a small increased
       risk of complications following BCG vaccination among HIV-1-infected
       children, but the reactions are usually mild and the risk does not
       outweigh the benefits of BCG vaccination in populations at high risk of
       tuberculosis during infancy and childhood.
 DE    Adult  BCG Vaccine/*ADVERSE EFFECTS  Cohort Studies  Disease
       Transmission, Vertical  Female  Human  *HIV Infections/TRANSMISSION  HIV
       Seronegativity  *HIV Seropositivity  Infant  Infant, Newborn  Support,
       U.S. Gov't, P.H.S.  JOURNAL ARTICLE  REVIEW  REVIEW OF REPORTED CASES

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