Document 0883
 DOCN  M9550883
 TI    Vertical Transmission of HIV-1. Correlation with maternal viral load and
       plasma levels of CD4 binding site anti-gp120 antibodies.
 DT    9505
 AU    Khouri YF; McIntosh K; Cavacini L; Posner M; Pagano M; Tuomala R;
       Marasco WA; Dana-Farber Cancer Institute, Division of Human
       Retrovirology,; Boston, Massachusetts 02115.
 SO    J Clin Invest. 1995 Feb;95(2):732-7. Unique Identifier : AIDSLINE
       MED/95164706
 AB    Almost all childhood HIV-1 is now acquired through vertical
       transmission. Identifying factors that affect the rate of transmission
       may lead to the initiation of specific preventive strategies. In this
       study, antibody levels against different neutralizing epitopes on the
       envelope glycoprotein of HIV-1 (gp120) were measured in HIV-1-infected
       pregnant women that either transmitted HIV-1 to their infants (18 women)
       or did not (29 women). Differences in levels of antibodies directed
       against the monomeric gp120 molecule and against the V3 loop region of
       gp120 were not significantly different between the two groups studied.
       However, significant differences were observed in the levels of CD4
       binding site antibodies, as determined by the ability of diluted
       maternal plasma to inhibit binding of the CD4 binding site monoclonal
       antibody F105 (mAb F105) to monomeric gp120. In addition, more
       nontransmitting mothers had low viral load as defined by having two or
       more negative HIV-1 viral cultures during pregnancy compared with
       transmitters. This pilot study suggests that in addition to higher viral
       load, low levels of CD4 binding site antibodies correlate with increased
       risk of HIV-1 vertical transmission. Passive immunotherapy with broadly
       neutralizing CD4 binding site antibodies should be considered as a
       strategy to reduce this risk.
 DE    Acquired Immunodeficiency Syndrome/BLOOD/IMMUNOLOGY/*TRANSMISSION  Adult
       Analysis of Variance  Biological Markers/BLOOD  Comparative Study  CD4
       Lymphocyte Count  *Disease Transmission, Vertical  Female  Human  HIV
       Antibodies/*BLOOD  HIV Envelope Protein gp120/*IMMUNOLOGY  HIV
       Seropositivity/BLOOD/IMMUNOLOGY/*TRANSMISSION  HIV-1/*ISOLATION & PURIF
       Pregnancy  Pregnancy Complications,
       Infectious/BLOOD/IMMUNOLOGY/*VIROLOGY  Support, Non-U.S. Gov't  Support,
       U.S. Gov't, P.H.S.  CLINICAL TRIAL  CONTROLLED CLINICAL TRIAL  JOURNAL
       ARTICLE  MULTICENTER STUDY

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).